Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 5/20 | 0.74 |
| ▸ | MEN1 | O00255 | 8/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.73 |
| ▸ | DUSP3 | P51452 | 5/20 | 0.72 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.72 |
| ▸ | POLB | P06746 | 3/20 | 0.72 |
| ▸ | PTPN12 | Q05209 | 3/20 | 0.72 |
| ▸ | BLM | P54132 | 2/20 | 0.72 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.72 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.72 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.70 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.70 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.70 |
| ▸ | CDC25B | P30305 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669368 | 1.00 | PTPN22 (0.74) | PTPN22MEN1KMT2ADUSP3PTPN7 | |
| SCHEMBL13855923 | 0.96 | MEN1 (0.79) | PTPN22MEN1KMT2ADUSP3PTPN7 | |
| SCHEMBL4669154 | 0.96 | MEN1 (0.80) | PTPN22MEN1KMT2ADUSP3PTPN7 | |
| SCHEMBL4669151 | 0.96 | MEN1 (0.80) | PTPN22MEN1KMT2ADUSP3PTPN7 | |
| SCHEMBL4669226 | 0.94 | MAPT (0.68) | PTPN22MEN1KMT2ADUSP3PTPN7 | |
| SCHEMBL4669224 | 0.94 | MAPT (0.68) | PTPN22MEN1KMT2ADUSP3PTPN7 | |
| SCHEMBL14104331 | 0.93 | PTPN22 (0.66) | PTPN22MEN1KMT2ADUSP3PTPN7 | |
| SCHEMBL4669378 | 0.91 | ALDH1A1 (0.81) | PTPN22MEN1KMT2ADUSP3PTPN7 | |
| SCHEMBL4669377 | 0.91 | ALDH1A1 (0.81) | PTPN22MEN1KMT2ADUSP3PTPN7 | |
| SCHEMBL4668142 | 0.90 | CDC25B (0.85) | PTPN22MEN1KMT2ADUSP3PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2000140-A1 | Use of derivatives of 3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine or of 3-oxo-2,3-dihydro-5H-imidazolo[3,2-a]pyrimidine for the preparation of pharmaceutical compositions intended for the treatment of cancer | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2008-12-10 | — | — | EP | disclosed |