Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.81 |
| ▸ | MEN1 | O00255 | 10/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.70 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.65 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.65 |
| ▸ | CDC25B | P30305 | 1/20 | 0.65 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.65 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.65 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.65 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.64 |
| ▸ | PTPN22 | Q9Y2R2 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669378 | 1.00 | ALDH1A1 (0.81) | ALDH1A1NPSR1MEN1KMT2ADNMT1 | |
| SCHEMBL4669054 | 0.92 | ALDH1A1 (0.78) | ALDH1A1NPSR1MEN1KMT2ADNMT1 | |
| SCHEMBL4669050 | 0.92 | ALDH1A1 (0.78) | ALDH1A1NPSR1MEN1KMT2ADNMT1 | |
| SCHEMBL13855947 | 0.91 | ALDH1A1 (0.87) | ALDH1A1NPSR1MEN1KMT2ADNMT1 | |
| SCHEMBL4669366 | 0.91 | PTPN22 (0.74) | ALDH1A1NPSR1MEN1KMT2ADNMT1 | |
| SCHEMBL4669368 | 0.91 | PTPN22 (0.74) | ALDH1A1NPSR1MEN1KMT2ADNMT1 | |
| SCHEMBL14103248 | 0.90 | ALDH1A1 (0.85) | ALDH1A1NPSR1MEN1KMT2ADNMT1 | |
| SCHEMBL4669224 | 0.89 | MAPT (0.68) | ALDH1A1NPSR1MEN1KMT2ADNMT1 | |
| SCHEMBL4669226 | 0.89 | MAPT (0.68) | ALDH1A1NPSR1MEN1KMT2ADNMT1 | |
| SCHEMBL13855923 | 0.87 | MEN1 (0.79) | ALDH1A1MEN1KMT2ADNMT1PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2000140-A1 | Use of derivatives of 3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine or of 3-oxo-2,3-dihydro-5H-imidazolo[3,2-a]pyrimidine for the preparation of pharmaceutical compositions intended for the treatment of cancer | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2008-12-10 | — | — | EP | disclosed |