SCHEMBL4669737

SCHEMBL4669737

O=C(O)COc1ccccc1CBr

nearest known ligand 0.65

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.65
POLB P06746 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
GLA P06280 1/20 0.58
PTGDR2 Q9Y5Y4 8/20 0.54
ALDH1A1 P00352 2/20 0.54
KDM4E B2RXH2 1/20 0.54
HPGD P15428 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
TBXAS1 P24557 2/20 0.52
ALOX15 P16050 1/20 0.52
PKM P14618 1/20 0.47
MAPT P10636 2/20 0.46
MEN1 O00255 1/20 0.46
PTPN7 P35236 1/20 0.46
KMT2A Q03164 1/20 0.46
PTPN12 Q05209 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2798208 0.85 HTT (0.59) L3MBTL1POLBSMN1; SMN2GLAKDM4E
SCHEMBL3409855 0.83 L3MBTL1 (0.67) L3MBTL1POLBSMN1; SMN2GLAPTGDR2
SCHEMBL266662 0.83 L3MBTL1 (0.72) L3MBTL1POLBSMN1; SMN2GLAPTGDR2
SCHEMBL503961 0.83 L3MBTL1 (0.77) L3MBTL1POLBSMN1; SMN2GLAPTGDR2
SCHEMBL7402587 0.83 KDM4E (0.61) L3MBTL1POLBSMN1; SMN2GLAPTGDR2
SCHEMBL29682135 0.82 L3MBTL1 (0.80) L3MBTL1POLBSMN1; SMN2GLAPTGDR2
SCHEMBL340762 0.82 L3MBTL1 (0.80) L3MBTL1POLBSMN1; SMN2GLAPTGDR2
SCHEMBL4300659 0.81 L3MBTL1 (0.65) L3MBTL1POLBSMN1; SMN2GLAPTGDR2
SCHEMBL4837994 0.81 L3MBTL1 (0.65) L3MBTL1POLBSMN1; SMN2GLAPTGDR2
SCHEMBL11204805 0.81 L3MBTL1 (0.65) L3MBTL1POLBSMN1; SMN2GLAPTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008144604-A1 SUBSTITUTED 2-METHYL-2-PHENOXY-N-PROPYL-PROPIONAMIDES AS CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING OBESITY JENRIN DISCOVERY (US) 2008-11-27 WO disclosed
US-20080287505-A1 SUBSTITUTED 2-METHYL-2-PHENOXY-N-PROPYL-PROPIONAMIDES AS CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING OBESITY JENRIN DISCOVERY (US) 2008-11-20 US disclosed
US-6010826-A Resist composition NIPPON ZEON CO., LTD. (JP) 2000-01-04 US disclosed
EP-0786701-A1 RESIST COMPOSITION NIPPON ZEON CO., LTD. (JP) 1997-07-30 EP disclosed
US-5545568-A ARRAY OF COMPOUNDS ON SUBSTRATE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-08-13 US disclosed
US-4668698-A [(4-phenyl-1,3-dioxan-cis-5-yl)alkyl]phenylalkanoic acid derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-05-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080287505-A1 SUBSTITUTED 2-METHYL-2-PHENOXY-N-PROPYL-PROPIONAMIDES AS CANNABINOID RECEPTOR ANTAGONISTS/INVERSE AGONISTS USEFUL FOR TREATING OBESITY CNR2, CNR1, GPR119 L3MBTL1 3370/4885POLB 3369/4885SMN1; SMN2 3640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.