Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450814 | 0.89 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3451607 | 0.87 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL4672854 | 0.85 | PDE4B (0.84) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3451767 | 0.85 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3452374 | 0.84 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3450802 | 0.82 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DTSHR | |
| SCHEMBL3453010 | 0.82 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4669096 | 0.79 | PDE4B (0.79) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3453181 | 0.78 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL4669091 | 0.76 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716133-B1 | 2-(PIPERIDIN-4-YL)-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2008-03-26 | — | — | EP | claimed |