Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670260 | 0.91 | CHEK2 (0.38) | CHEK2SYKPARP10JAK2MAPK1 | |
| SCHEMBL4675730 | 0.89 | CHEK2 (0.37) | CHEK2MAP4K4MEN1MAPTKMT2A | |
| SCHEMBL4673486 | 0.89 | MET (0.39) | PLAUCHEK2METSYKPARP1 | |
| SCHEMBL4672813 | 0.88 | XDH (0.35) | TP53MAPT | |
| SCHEMBL4672855 | 0.80 | NCEH1 (0.38) | MEN1MAPTKMT2AMAPK1 | |
| SCHEMBL4674152 | 0.79 | PLAU (0.45) | PLAUPLATCHEK2MAP4K4HPGDS | |
| SCHEMBL4673753 | 0.78 | PARP10 (0.43) | CHEK2HPGDSPARP10MAPT | |
| SCHEMBL4670264 | 0.75 | ROCK1 (0.36) | MEN1MAPTKMT2AMAPK1 | |
| SCHEMBL4672254 | 0.73 | PARP10 (0.51) | PLAUPLATCHEK2MAP4K4HPGDS | |
| SCHEMBL4675739 | 0.73 | ROCK1 (0.36) | MEN1MAPTKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |