Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | DRD5 | P21918 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670703 | 0.83 | HTR2C (0.58) | GPR84SLC6A4HTR2CADRB2NR4A2 | |
| Bromide SCHEMBL7867381 | 0.78 | HTR1F (0.52) | GPR84SLC6A4HTR1AHTR1F | |
| SCHEMBL1601125 | 0.74 | HTR2C (0.68) | HTR2CADRB2HTR2AHTR2B | |
| SCHEMBL8876433 | 0.72 | SLC6A4 (0.61) | SLC6A4CCR2 | |
| SCHEMBL5584834 | 0.72 | HTR2A (0.42) | SLC6A4HTR2CHTR1AGAAIDO1 | |
| SCHEMBL3962246 | 0.71 | TP53 (0.48) | SLC6A4HTR2COPRL1HTR1AHTR2A | |
| SCHEMBL5389620 | 0.71 | CCR2 (0.48) | HTR1FHTR2ADRD2CCR2 | |
| SCHEMBL4675206 | 0.70 | SLC6A4 (0.58) | GPR84SLC6A4HTR2CADRB2OPRM1 | |
| SCHEMBL4674713 | 0.70 | SLC6A4 (0.58) | GPR84SLC6A4HTR2CADRB2OPRM1 | |
| SCHEMBL5384995 | 0.69 | CCR2 (0.51) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |