Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.40 |
| ▸ | HTR1A | P08908 | 6/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | HTR7 | P34969 | 6/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670811 | 0.73 | HTR6 (0.59) | HTR6SLC6A4HTR1ADRD2HTR7 | |
| SCHEMBL4673642 | 0.71 | HTR6 (0.73) | HTR6 | |
| SCHEMBL8208940 | 0.70 | HTR6 (0.46) | HTR6HTR1AHTR7HSD11B1 | |
| SCHEMBL4673182 | 0.65 | SLC6A4 (0.46) | HTR6SLC6A4HTR7 | |
| SCHEMBL7483861 | 0.64 | HTR6 (0.66) | HTR6SLC6A4 | |
| SCHEMBL4676506 | 0.63 | SLC6A4 (0.65) | HTR6SLC6A4HTR1A | |
| SCHEMBL4673107 | 0.62 | HTR6 (0.77) | HTR6SLC6A4HTR1ADRD2HTR7 | |
| SCHEMBL4671257 | 0.62 | HTR6 (0.68) | HTR6SLC6A4 | |
| SCHEMBL4673300 | 0.62 | HTR6 (0.61) | HTR6SLC6A4 | |
| SCHEMBL7485051 | 0.61 | HTR6 (0.79) | HTR6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-B9 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2008-10-15 | — | — | EP | disclosed |
| EP-1173432-B1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2007-10-17 | — | — | EP | disclosed |