Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18324808 | 0.82 | SLC6A4 (0.45) | SLC6A4LMNAPOLB | |
| SCHEMBL7864918 | 0.82 | SLC6A4 (0.64) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| Bromide SCHEMBL7870740 | 0.81 | SLC6A4 (0.62) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL4673448 | 0.79 | SLC6A4 (1.00) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL7859785 | 0.78 | SLC6A4 (0.72) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| Bromide SCHEMBL7867371 | 0.78 | SLC6A4 (0.97) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL7865112 | 0.76 | SLC6A4 (0.81) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL5372625 | 0.73 | SLC6A4 (0.65) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL5038673 | 0.73 | SLC6A4 (0.60) | SLC6A4 | |
| SCHEMBL5369488 | 0.73 | SLC6A4 (0.64) | SLC6A4KDM4ELMNAPOLBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-B9 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2008-10-15 | — | — | EP | disclosed |
| EP-1173432-B1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2007-10-17 | — | — | EP | disclosed |
| US-6133287-A | SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS, E.G., PSYCHOSIS, SCHIZOPHRENIA, MANIC DEPRESSION, DEPRESSION, MEMORY DISTURBANCES, PARKINSONISM, AMYLOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-17 | — | — | US | disclosed |