Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 7/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670960 | 0.99 | PRKDC (0.39) | PRKDCDPP4ADORA2AADORA1KDM4E | |
| SCHEMBL4677173 | 0.99 | PRKDC (0.39) | PRKDCDPP4ADORA2AADORA1KDM4E | |
| SCHEMBL4676232 | 0.99 | PRKDC (0.39) | PRKDCDPP4ADORA2AADORA1KDM4E | |
| SCHEMBL4673869 | 0.99 | PRKDC (0.39) | PRKDCDPP4ADORA2AADORA1KDM4E | |
| SCHEMBL4671088 | 0.95 | HTT (0.35) | PRKDCDPP4SMN1; SMN2HTT | |
| SCHEMBL4673267 | 0.95 | HTT (0.35) | PRKDCDPP4SMN1; SMN2HTT | |
| SCHEMBL4673163 | 0.95 | HTT (0.35) | PRKDCDPP4SMN1; SMN2HTT | |
| SCHEMBL4674836 | 0.95 | HTT (0.35) | PRKDCDPP4SMN1; SMN2HTT | |
| SCHEMBL6321380 | 0.95 | HTT (0.35) | PRKDCDPP4SMN1; SMN2HTT | |
| SCHEMBL4670953 | 0.89 | IDH1 (0.33) | PRKDCSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461330-B1 | 3H-NAPHTHO[2,1-b]-PYRANE DERIVATIVES AND THEIR USE | RODENSTOCK GMBH (DE) | 2008-03-12 | — | — | EP | claimed |
| US-6967249-B2 | Photochromic 3H-naphtho[2,1-b]-pyran compounds and photochromic articles produced therewith | RODENSTOCK GMBH (DE) | 2005-11-22 | — | — | US | claimed |
| US-20040267013-A1 | Photochromic 3H-naphtho[2,1-b]-pyran compounds and photochromic articles produced therewith | RODENSTOCK GMBH | 2004-12-30 | — | — | US | claimed |
| EP-1461330-A1 | 3H-NAPHTHO 2,1-B]-PYRANE DERIVATIVES AND THE USE OF THE SAME | Rodenstock GmbH (DE) | 2004-09-29 | — | — | EP | claimed |
| WO-2003055872-A1 | 3H-NAPHTHO[2,1-B]-PYRANE DERIVATIVES AND THE USE OF THE SAME | RODENSTOCK GMBH (DE) | 2003-07-10 | — | — | WO | claimed |
| EP-1461330-B1 | 3H-NAPHTHO[2,1-b]-PYRANE DERIVATIVES AND THEIR USE | RODENSTOCK GMBH (DE) | 2008-03-12 | — | — | EP | disclosed |
| US-6967249-B2 | Photochromic 3H-naphtho[2,1-b]-pyran compounds and photochromic articles produced therewith | RODENSTOCK GMBH (DE) | 2005-11-22 | — | — | US | disclosed |
| US-20040267013-A1 | Photochromic 3H-naphtho[2,1-b]-pyran compounds and photochromic articles produced therewith | RODENSTOCK GMBH | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040267013-A1 | Photochromic 3H-naphtho[2,1-b]-pyran compounds and photochromic articles produced therewith | RB1, TERB1, CRY2 | PRKDC 2885/4885DPP4 3541/4885ADORA2A 3476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.