Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.56 |
| ▸ | MGLL | Q99685 | 3/20 | 0.55 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023293 | 0.88 | HSD11B1 (0.63) | HSD11B1MGLLKDM2BCES2CES1 | |
| SCHEMBL1855141 | 0.84 | HSD11B1 (0.60) | HSD11B1MGLLKDM2BCES2CES1 | |
| SCHEMBL19650840 | 0.84 | HSD11B1 (0.60) | HSD11B1MGLLKDM2BCES2CES1 | |
| SCHEMBL4671079 | 0.83 | MEN1 (0.56) | MAPTLMNAGAAMEN1ALDH1A1 | |
| SCHEMBL26081057 | 0.83 | HSD11B1 (0.58) | HSD11B1MGLLKDM2BCES2CES1 | |
| SCHEMBL4671500 | 0.81 | HSD11B1 (0.58) | HSD11B1MGLLPOLBGAAALDH1A1 | |
| SCHEMBL4240412 | 0.80 | MEN1 (0.61) | HSD11B1MGLLKDM2BCES2CES1 | |
| SCHEMBL4672863 | 0.79 | KDM4E (0.53) | HSD11B1MGLLPOLBLMNAGAA | |
| Hydrochloric Acid SCHEMBL21384816 | 0.79 | MEN1 (0.64) | HSD11B1MGLLKDM2BCES2CES1 | |
| SCHEMBL4673866 | 0.77 | MGLL (0.51) | HSD11B1MGLLCES2CES1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |