Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4676670 | 0.88 | SLC6A4 (0.58) | SLC6A4OPRM1OPRL1HTR2AIDO1 | |
| SCHEMBL2904310 | 0.83 | HTR2A (0.64) | SLC6A4DRD2ADRA1DOPRM1OPRL1 | |
| SCHEMBL30275187 | 0.83 | HTR2A (0.64) | SLC6A4DRD2ADRA1DOPRM1OPRL1 | |
| Hydrochloric Acid SCHEMBL6248133 | 0.82 | HTR2C (0.63) | SLC6A4DRD2ADRA1DOPRM1OPRL1 | |
| SCHEMBL4675206 | 0.82 | SLC6A4 (0.58) | SLC6A4DRD2OPRM1OPRL1IDO1 | |
| SCHEMBL4676876 | 0.82 | IDO1 (0.50) | SLC6A4DRD2ADRA1DHTR2AIDO1 | |
| SCHEMBL4354945 | 0.81 | SLC6A4 (0.61) | SLC6A4DRD2ADRA1DOPRM1OPRL1 | |
| SCHEMBL6636763 | 0.81 | DRD2 (0.57) | SLC6A4DRD2ADRA1DOPRM1OPRL1 | |
| SCHEMBL31295173 | 0.80 | HTR2A (0.59) | SLC6A4DRD2ADRA1DOPRM1OPRL1 | |
| SCHEMBL18324781 | 0.79 | DRD2 (0.59) | SLC6A4DRD2ADRA1DOPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |