SCHEMBL4671235

SCHEMBL4671235

COC(=O)[C@@H](C(C)C)N(Cc1ccccc1)S(=O)(=O)N(C)Cc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.59
TSHR P16473 1/20 0.50
MMP2 P08253 7/20 0.49
MMP9 P14780 7/20 0.49
MMP8 P22894 6/20 0.49
MMP13 P45452 5/20 0.49
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
MMP1 P03956 1/20 0.46
KMT2A Q03164 4/20 0.44
MEN1 O00255 3/20 0.43
HTT P42858 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27392969 0.85 MMP9 (0.66) TSHRMMP2MMP9MMP8MMP13
SCHEMBL4675367 0.83 ATM (0.60) ATMTSHRMMP2MMP9MMP8
SCHEMBL4675370 0.83 ATM (0.60) ATMTSHRMMP2MMP9MMP8
SCHEMBL17559609 0.79 ATM (0.52) ATMMMP2MMP9MMP8MMP13
SCHEMBL17559610 0.79 ATM (0.52) ATMMMP2MMP9MMP8MMP13
SCHEMBL4671232 0.79 ATM (0.56) ATMTSHRMMP2MMP9MMP8
SCHEMBL4671238 0.79 ATM (0.56) ATMTSHRMMP2MMP9MMP8
SCHEMBL27419296 0.76 ATM (0.59) ATMTSHRMMP2MMP9MMP8
SCHEMBL27465010 0.73 ATM (0.55) ATMTSHRMMP2MMP9MMP8
SCHEMBL19520999 0.72 KMT2A (0.46) ATMKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958287-B2 SULFAMIDE-METALLOPROTEASE INHIBITORS HOFFMANN LA ROCHE (CH) 2008-04-09 EP disclosed
EP-0958287-B1 SULFAMIDE-METALLOPROTEASE INHIBITORS HOFFMANN LA ROCHE (CH) 2002-09-11 EP disclosed
US-6376506-B1 REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS SYNTEX (U.S.A.) LLC 2002-04-23 US disclosed
US-6143744-A Sulfamide-metalloprotease inhibitors SYNTEX (U.S.A.) INC. (US) 2000-11-07 US disclosed
US-6130220-A ENZYME INHIBITORS SYNTEX (USA) INC. (US) 2000-10-10 US disclosed
US-5998412-A ANTIARTHRITIC AGENTS; OSTEOPOROSIS SYNTEX (U.S.A.) INC. (US) 1999-12-07 US disclosed
EP-0958287-A1 SULFAMIDE-METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 1999-11-24 EP disclosed
WO-1998032748-A1 SULFAMIDE-METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 1998-07-30 WO disclosed