Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671794 | 1.00 | SIGMAR1 (0.44) | SIGMAR1AVPR1AEPHX2CA12CA1 | |
| SCHEMBL3870289 | 0.94 | AVPR1A (0.46) | SIGMAR1AVPR1ACA12CA1CA2 | |
| SCHEMBL3870291 | 0.94 | AVPR1A (0.46) | SIGMAR1AVPR1ACA12CA1CA2 | |
| SCHEMBL3871878 | 0.89 | AVPR1A (0.50) | SIGMAR1AVPR1ACA12CA1CA2 | |
| SCHEMBL3871881 | 0.89 | AVPR1A (0.50) | SIGMAR1AVPR1ACA12CA1CA2 | |
| SCHEMBL3869562 | 0.88 | EPHX2 (0.54) | SIGMAR1AVPR1AEPHX2MAPTMAPK1 | |
| SCHEMBL3869565 | 0.88 | EPHX2 (0.54) | SIGMAR1AVPR1AEPHX2MAPTMAPK1 | |
| SCHEMBL3869577 | 0.82 | EPHX2 (0.60) | SIGMAR1AVPR1AEPHX2MAPTMAPK1 | |
| SCHEMBL3872069 | 0.82 | EPHX2 (0.60) | SIGMAR1AVPR1AEPHX2MAPTMAPK1 | |
| SCHEMBL3869069 | 0.75 | CCR2 (0.69) | CCR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891064-A1 | N-AMIDE DERIVATIVES OF 8-AZABICYCLO[3.2.1]OCT-3-YL AS CCR1 ANTAGONISTS | Laboratorios Almirall, S.A. (ES) | 2008-02-27 | — | — | EP | claimed |
| WO-2006133802-A1 | N-AMIDE DERIVATIVES OF 8-AZABICYCLO[3.2.1]OCT-3-YL AS CCR1 ANTAGONISTS | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-12-21 | — | — | WO | claimed |