Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8761852 | 0.82 | DPP4 (0.52) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL8761844 | 0.82 | DPP4 (0.52) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL1358135 | 0.82 | DPP4 (0.52) | DPP4F2ADRA2AADRA2CLMNA | |
| Hydrochloric Acid SCHEMBL23292667 | 0.80 | DPP4 (0.50) | DPP4F2ADRA2AADRA2CLMNA | |
| Hydrochloric Acid SCHEMBL197657 | 0.80 | DPP4 (0.50) | DPP4F2ADRA2AADRA2CLMNA | |
| Water SCHEMBL8528911 | 0.80 | DPP4 (0.50) | DPP4F2ADRA2AADRA2CLMNA | |
| Iodide SCHEMBL4994551 | 0.80 | DPP4 (0.50) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL1751595 | 0.78 | DPP4 (0.48) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL1152702 | 0.76 | ADRA2A (0.46) | DPP4F2ADRA2AADRA2CLMNA | |
| SCHEMBL1152705 | 0.76 | ADRA2A (0.46) | DPP4F2ADRA2AADRA2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042293-B9 | SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | AMGEN INC (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1042293-B1 | SUBSTITUTED PYRIDINE AND PYRIDAZINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | AMGEN INC (US) | 2008-03-19 | — | — | EP | disclosed |