SCHEMBL4672114

SCHEMBL4672114

Cn1ncc(C(=O)Nc2ccccc2SC(F)(F)F)c1N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
L3MBTL1 Q9Y468 3/20 0.46
PKM P14618 2/20 0.46
HTT P42858 2/20 0.46
HPGD P15428 1/20 0.46
EPHB3 P54753 2/20 0.41
SCN9A Q15858 2/20 0.40
KCNK2 O95069 1/20 0.40
KCNK10 P57789 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
GAA P10253 1/20 0.39
MAPK14 Q16539 3/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
TSHR P16473 1/20 0.39
LMNA P02545 1/20 0.39
NR3C1 P04150 1/20 0.39
TP53 P04637 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11198610 0.81 ATM (0.55) PKMHTTNPC1RAB9AMAPK14
SCHEMBL11194508 0.81 RAB9A (0.58) ALDH1A1L3MBTL1HTTHPGDEPHB3
SCHEMBL11192921 0.79 EPHB3 (0.57) HPGDEPHB3NPC1RAB9ACYP1A2
SCHEMBL11204732 0.78 HSD17B10 (0.48) ALDH1A1HPGDGAAMAPK14CYP1A2
SCHEMBL11197057 0.77 ALDH1A1 (0.54) ALDH1A1L3MBTL1EPHB3SCN9ANPC1
SCHEMBL939409 0.75 NPC1 (0.52) ALDH1A1PKMHTTHPGDSCN9A
SCHEMBL11196150 0.72 MAPK14 (0.42) ALDH1A1HTTEPHB3SCN9ANPC1
SCHEMBL31473324 0.72 GAA (0.50) ALDH1A1EPHB3SCN9ANPC1RAB9A
SCHEMBL11200983 0.72 GAA (0.50) ALDH1A1SCN9ANPC1RAB9AGAA
SCHEMBL31473317 0.72 CYP1A2 (0.46) ALDH1A1HTTNPC1RAB9AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1891047-A4 1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS BAYER HEALTHCARE AG (DE) 2008-07-09 EP disclosed
EP-1891047-A2 1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS Bayer HealthCare AG (DE) 2008-02-27 EP disclosed
WO-2006133006-A2 1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS BAYER HEALTHCARE AG (DE) 2006-12-14 WO disclosed