Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 4/20 | 0.59 |
| ▸ | SLC22A12 | Q96S37 | 16/20 | 0.45 |
| ▸ | VEGFA | P15692 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638354 | 0.88 | EPAS1 (0.46) | EPAS1SLC22A12VEGFA | |
| SCHEMBL4637412 | 0.85 | PTGS2 (0.43) | EPAS1 | |
| SCHEMBL4639019 | 0.82 | EPAS1 (0.44) | EPAS1 | |
| SCHEMBL4638189 | 0.79 | EPAS1 (0.39) | EPAS1 | |
| SCHEMBL4637450 | 0.77 | PTGS2 (0.42) | EPAS1 | |
| SCHEMBL10950817 | 0.77 | EPAS1 (0.65) | EPAS1SLC22A12 | |
| SCHEMBL883929 | 0.75 | EPAS1 (0.50) | EPAS1SLC22A12 | |
| SCHEMBL10051874 | 0.74 | EPAS1 (0.55) | EPAS1 | |
| SCHEMBL16556042 | 0.74 | EPAS1 (1.00) | EPAS1SLC22A12VEGFA | |
| SCHEMBL4195364 | 0.73 | EPAS1 (0.51) | EPAS1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |