Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637412 | 0.88 | PTGS2 (0.43) | EPAS1PTGS2PTGS1BRD4SMN1; SMN2 | |
| SCHEMBL4637426 | 0.87 | PTGDR2 (0.42) | EPAS1BRD4 | |
| SCHEMBL4638189 | 0.84 | EPAS1 (0.39) | EPAS1PTGS2PTGS1BRD4SMN1; SMN2 | |
| SCHEMBL4637551 | 0.84 | CYP1A2 (0.39) | — | |
| SCHEMBL4672154 | 0.82 | EPAS1 (0.59) | EPAS1 | |
| SCHEMBL4637450 | 0.79 | PTGS2 (0.42) | EPAS1PTGS2PTGS1 | |
| SCHEMBL4637444 | 0.77 | EPAS1 (0.53) | EPAS1PTGS2PTGS1BRD4 | |
| SCHEMBL4637479 | 0.75 | PTGDR2 (0.41) | EPAS1BRD4SMN1; SMN2 | |
| SCHEMBL4638324 | 0.74 | KIF11 (0.43) | EPAS1PTGS2PTGS1BRD4SMN1; SMN2 | |
| SCHEMBL1692088 | 0.72 | SLC6A2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |