Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.60 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672241 | 1.00 | GRIN2B (0.60) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4672504 | 0.91 | GRIN2B (0.59) | GRIN2BGRIN1MAOB | |
| SCHEMBL4672506 | 0.91 | GRIN2B (0.59) | GRIN2BGRIN1MAOB | |
| SCHEMBL10837456 | 0.81 | GRIN2B (0.58) | GRIN2BGRIN1MAOB | |
| SCHEMBL10837463 | 0.81 | GRIN2B (0.58) | GRIN2BGRIN1MAOB | |
| SCHEMBL4672719 | 0.79 | GRIN2B (0.66) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4672713 | 0.79 | GRIN2B (0.66) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4671945 | 0.79 | GRIN2B (0.58) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL27433120 | 0.78 | GRIN2B (0.58) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL7237621 | 0.77 | GRIN2B (0.61) | GRIN2BSLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068202-B1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2008-12-03 | — | — | EP | claimed |
| US-6548516-B1 | (NMDA=N-methyl-D-aspartate); where the heteroaryl is 3H-benzoxazol-2-one, 3H-benzothiazol-2-one, 3H-benzimidazol-2-one or indolin-2-one; excitatory amino acid antagonists for combating neurodegenerative disorders | MERCK PATENT GMBH (DE) | 2003-04-15 | — | — | US | claimed |
| EP-1068202-B1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2008-12-03 | — | — | EP | disclosed |
| US-6548516-B1 | (NMDA=N-methyl-D-aspartate); where the heteroaryl is 3H-benzoxazol-2-one, 3H-benzothiazol-2-one, 3H-benzimidazol-2-one or indolin-2-one; excitatory amino acid antagonists for combating neurodegenerative disorders | MERCK PATENT GMBH (DE) | 2003-04-15 | — | — | US | disclosed |
| EP-1068202-A1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999048891-A1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1999-09-30 | — | — | WO | disclosed |