Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.58 |
| ▸ | MAOA | P21397 | 4/20 | 0.52 |
| ▸ | MAOB | P27338 | 4/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.50 |
| ▸ | OGT | O15294 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10837463 | 1.00 | GRIN2B (0.58) | GRIN2BMAOAMAOBGRIN1OGT | |
| SCHEMBL4672506 | 0.90 | GRIN2B (0.59) | GRIN2BMAOAMAOBGRIN1OGT | |
| SCHEMBL4672504 | 0.90 | GRIN2B (0.59) | GRIN2BMAOAMAOBGRIN1OGT | |
| SCHEMBL10837487 | 0.86 | MAOA (0.51) | MAOAMAOBBCHEACHETBXAS1 | |
| SCHEMBL10837483 | 0.86 | MAOA (0.51) | MAOAMAOBBCHEACHETBXAS1 | |
| SCHEMBL10836311 | 0.86 | KDM1A (0.44) | GRIN2BMAOAMAOBTBXAS1PDE3B | |
| SCHEMBL10836308 | 0.86 | KDM1A (0.44) | GRIN2BMAOAMAOBTBXAS1PDE3B | |
| SCHEMBL10837555 | 0.82 | DRD2 (0.50) | MAOAMAOBTBXAS1PDE3BPDE3A | |
| SCHEMBL10837548 | 0.82 | DRD2 (0.50) | MAOAMAOBTBXAS1PDE3BPDE3A | |
| SCHEMBL4672241 | 0.81 | GRIN2B (0.60) | GRIN2BMAOBGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | claimed |
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |