Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | OGT | O15294 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672506 | 1.00 | GRIN2B (0.59) | GRIN2BGRIN1MAOAMAOBCCR3 | |
| SCHEMBL4672245 | 0.91 | GRIN2B (0.60) | GRIN2BGRIN1MAOB | |
| SCHEMBL4672241 | 0.91 | GRIN2B (0.60) | GRIN2BGRIN1MAOB | |
| SCHEMBL10837463 | 0.90 | GRIN2B (0.58) | GRIN2BGRIN1MAOAMAOBOGT | |
| SCHEMBL10837456 | 0.90 | GRIN2B (0.58) | GRIN2BGRIN1MAOAMAOBOGT | |
| SCHEMBL4672244 | 0.79 | GRIN2B (0.57) | GRIN2BGRIN1MAOAMAOBCCR3 | |
| SCHEMBL4672509 | 0.79 | GRIN2B (0.46) | GRIN2BMAOAMAOBCCR3 | |
| SCHEMBL4672713 | 0.78 | GRIN2B (0.66) | GRIN2BGRIN1 | |
| SCHEMBL4672719 | 0.78 | GRIN2B (0.66) | GRIN2BGRIN1 | |
| SCHEMBL10836308 | 0.78 | KDM1A (0.44) | GRIN2BMAOAMAOBCCR3TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068202-B1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1068202-A1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999048891-A1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1999-09-30 | — | — | WO | disclosed |