Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4676736 | 0.90 | POLB (0.37) | ALDH1A1NPSR1LMNARAB9AGAA | |
| SCHEMBL4671745 | 0.89 | MMP1 (0.33) | ALDH1A1HTTNPC1MAPTLMNA | |
| SCHEMBL4676058 | 0.83 | PTGER3 (0.35) | ALDH1A1HTTNPC1NPSR1MAPT | |
| SCHEMBL4671618 | 0.83 | ALDH1A1 (0.36) | ALDH1A1HTTNPC1NPSR1MAPT | |
| SCHEMBL4676016 | 0.80 | MAPT (0.40) | ALDH1A1HTTNPC1NPSR1MAPT | |
| SCHEMBL4672341 | 0.80 | SMN1; SMN2 (0.35) | ALDH1A1HTTMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL4678613 | 0.79 | ALDH1A1 (0.33) | ALDH1A1HTTNPC1NPSR1MAPT | |
| SCHEMBL4673979 | 0.78 | NAMPT (0.33) | ALDH1A1HTTMAPTHSP90AA1SMN1; SMN2 | |
| SCHEMBL4675361 | 0.78 | NAMPT (0.33) | ALDH1A1MAPTSMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL4680019 | 0.78 | ALDH1A1 (0.35) | ALDH1A1HTTNPC1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142872-B1 | AROMATIC HETEROCYCLE COMPOUNDS HAVING HIV INTEGRASE INHIBITING ACTIVITIES | SHIONOGI & CO (JP) | 2008-10-15 | — | — | EP | disclosed |
| US-6620841-B1 | Furan or benzofuran derivatives substituted with triazole; acquired immunodeficiency syndrome (AIDS) | SHIONOGI & CO., LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| EP-1142872-A1 | AROMATIC HETEROCYCLE COMPOUNDS HAVING HIV INTEGRASE INHIBITING ACTIVITIES | SHIONOGI & CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |