Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9750629 | 0.87 | MEN1 (0.48) | DDB1CRBNMEN1KMT2ADDAH1 | |
| SCHEMBL12949506 | 0.81 | MAOA (0.53) | DDB1CRBNMEN1KMT2ADDAH1 | |
| SCHEMBL3128507 | 0.81 | CARM1 (0.44) | DDB1CRBNPTGIRMAOAMAOB | |
| SCHEMBL15015409 | 0.78 | DDB1 (0.40) | DDB1CRBNMEN1KMT2ADDAH1 | |
| SCHEMBL4671081 | 0.78 | CRBN (0.41) | DDB1CRBNMEN1KMT2APTGIR | |
| SCHEMBL4670744 | 0.78 | MEN1 (0.45) | DDB1CRBNMEN1KMT2ADDAH1 | |
| SCHEMBL3123653 | 0.78 | CRBN (0.41) | DDB1CRBNMEN1KMT2APTGIR | |
| Hydrochloric Acid SCHEMBL5269331 | 0.76 | MEN1 (0.44) | DDB1CRBNMEN1KMT2ADDAH1 | |
| SCHEMBL12676793 | 0.75 | CARM1 (0.43) | DDB1CRBNMEN1KMT2ADDAH1 | |
| SCHEMBL8111506 | 0.72 | HRH3 (0.38) | DDB1CRBNMEN1KMT2ADDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |