Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.43 |
| ▸ | NCEH1 | Q6PIU2 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675977 | 0.92 | PTPN1 (0.49) | PTPN1NCEH1RAB9ANPC1MAPT | |
| SCHEMBL4675976 | 0.89 | PTPN1 (0.39) | PTPN1NCEH1RAB9AL3MBTL1NPC1 | |
| SCHEMBL4674024 | 0.84 | PTPN1 (0.43) | PTPN1NCEH1RAB9ANPC1MAPT | |
| SCHEMBL4672473 | 0.83 | PTPN1 (0.51) | PTPN1NCEH1 | |
| SCHEMBL4670378 | 0.80 | PTPN1 (0.40) | PTPN1NCEH1RAB9ANPC1MAPT | |
| SCHEMBL4785214 | 0.79 | NCEH1 (0.38) | NCEH1RAB9ALMNANPC1MAPT | |
| SCHEMBL4783722 | 0.78 | NCEH1 (0.40) | PTPN1NCEH1RAB9ALMNANPC1 | |
| SCHEMBL4670790 | 0.78 | PTPN1 (0.44) | PTPN1NCEH1RAB9ANPC1MAPT | |
| SCHEMBL4670748 | 0.78 | PTPN1 (0.41) | PTPN1NCEH1RAB9ALMNANPC1 | |
| SCHEMBL4674079 | 0.78 | PTPN1 (0.52) | PTPN1NCEH1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |