Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 8/20 | 0.40 |
| ▸ | PRKCB | P05771 | 2/20 | 0.35 |
| ▸ | PRKCA | P17252 | 2/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.35 |
| ▸ | PRKCH | P24723 | 1/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785214 | 0.90 | NCEH1 (0.38) | NCEH1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4783542 | 0.83 | NCEH1 (0.41) | NCEH1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4675976 | 0.81 | PTPN1 (0.39) | NCEH1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4674024 | 0.80 | PTPN1 (0.43) | NCEH1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4781322 | 0.79 | NCEH1 (0.43) | NCEH1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4673192 | 0.78 | PTPN1 (0.43) | NCEH1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4675977 | 0.78 | PTPN1 (0.49) | NCEH1SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL4672473 | 0.78 | PTPN1 (0.51) | NCEH1PTPN1 | |
| SCHEMBL4673082 | 0.76 | NCEH1 (0.36) | NCEH1MAPT | |
| SCHEMBL3979138 | 0.75 | ROCK1 (0.42) | MAPTABCG2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |