Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 5/20 | 0.71 |
| ▸ | HTR1D | P28221 | 4/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | THPO | P40225 | 1/20 | 0.71 |
| ▸ | HTR1A | P08908 | 3/20 | 0.65 |
| ▸ | HTR1F | P30939 | 2/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.64 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.64 |
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30877857 | 0.92 | KDM4E (0.67) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29206549 | 0.92 | KDM4E (0.67) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| Bromide SCHEMBL7870891 | 0.87 | DRD2 (0.73) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL7867314 | 0.87 | DRD2 (0.73) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27548381 | 0.85 | HTR1B (0.69) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30877339 | 0.85 | SLC6A4 (0.58) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7475958 | 0.84 | HTR1D (0.72) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23010847 | 0.84 | HTR1D (0.72) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30877197 | 0.84 | SLC6A4 (0.59) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8109656 | 0.83 | OPRM1 (0.68) | HTR1BHTR1AOPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173432-B9 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2008-10-15 | — | — | EP | disclosed |
| EP-1173432-B1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2007-10-17 | — | — | EP | disclosed |
| CN-1307573-A | Indolyl derivatives and serotonergic agents | AMERICAN HOME PROD (US) | 2001-08-08 | — | — | CN | disclosed |
| US-6133287-A | SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS, E.G., PSYCHOSIS, SCHIZOPHRENIA, MANIC DEPRESSION, DEPRESSION, MEMORY DISTURBANCES, PARKINSONISM, AMYLOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-17 | — | — | US | disclosed |