Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.55 |
| ▸ | NOS3 | P29474 | 1/20 | 0.55 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6931488 | 0.86 | NOS2 (0.55) | NOS2NOS3PRKCIKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6690850 | 0.85 | NOS2 (0.56) | NOS2NOS3PRKCIPIK3CBKDM4E | |
| SCHEMBL14141522 | 0.83 | NOS2 (0.51) | NOS2NOS3PRKCIKDM4EALDH1A1 | |
| SCHEMBL8597943 | 0.82 | KDM4E (0.40) | NOS2NOS3PIK3CBKDM4EALDH1A1 | |
| SCHEMBL19439176 | 0.82 | CCNC (0.41) | NOS2NOS3PRKCIPIK3CBKDM4E | |
| SCHEMBL30963968 | 0.81 | KDM4E (0.39) | NOS2NOS3PRKCIPIK3CBKDM4E | |
| SCHEMBL5718475 | 0.77 | CYP17A1 (0.46) | NOS2NOS3PRKCIPIK3CBKDM4E | |
| SCHEMBL1018547 | 0.76 | PARP1 (0.42) | KDM4EALDH1A1HPGDHSD17B10PARP1 | |
| SCHEMBL28917190 | 0.76 | PRKCI (0.40) | PRKCIKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5169967 | 0.76 | NOS3 (0.52) | NOS2NOS3PIK3CBKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |