Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fasudil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 known ✓ | O75116 | 8/20 | 1.00 |
| ▸ | ROCK1 known ✓ | Q13464 | 8/20 | 1.00 |
| ▸ | PRKCE | Q02156 | 6/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 6/20 | 1.00 |
| ▸ | PRKD1 | Q15139 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 5/20 | 1.00 |
| ▸ | PRKCG | P05129 | 5/20 | 1.00 |
| ▸ | PRKCB | P05771 | 5/20 | 1.00 |
| ▸ | PRKCA | P17252 | 5/20 | 1.00 |
| ▸ | PRKCH | P24723 | 5/20 | 1.00 |
| ▸ | PRKCI | P41743 | 5/20 | 1.00 |
| ▸ | PRKCQ | Q04759 | 5/20 | 1.00 |
| ▸ | PRKCZ | Q05513 | 5/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 5/20 | 1.00 |
| ▸ | PRKACA | P17612 | 4/20 | 1.00 |
| ▸ | PRKACG | P22612 | 4/20 | 1.00 |
| ▸ | PRKACB | P22694 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fasudil SCHEMBL29381868 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Fasudil SCHEMBL6269832 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Fasudil SCHEMBL29362990 | 1.00 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Fasudil SCHEMBL599053 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Fasudil SCHEMBL6032335 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Fasudil SCHEMBL678615 | 0.99 | ROCK2 (0.98) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Fasudil SCHEMBL30084458 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Fasudil SCHEMBL29393852 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Fasudil SCHEMBL317082 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Fasudil SCHEMBL29351490 | 0.99 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 13455 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746855-A1 | FORMULATIONS AND USES OF ROCK2 INHIBITORS FOR ALS | Graviton Bioscience BV (NL) | 2026-05-27 | — | — | EP | claimed |
| CN-122094667-A | Formulations and uses of ROCK2 inhibitors for ALS | — | 2026-05-26 | — | — | CN | claimed |
| EP-4744663-A2 | SKIN COMPOSITION | Eaderm Co., Ltd. (JP) | 2026-05-20 | — | — | EP | claimed |
| CN-122060666-A | Lipid combination, culture medium and method for multidirectional differentiation of human induced pluripotent stem cells into three germ layers and application of lipid combination and culture medium | 上海昂朴生物科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122036817-A | C-alkyl carbon glycoside and preparation method thereof | 江西师范大学 | 2026-05-15 | — | — | CN | claimed |
| US-20260132380-A1 | Hepatocyte Expansion Methods | KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN (NL) | 2026-05-14 | — | — | US | claimed |
| WO-2026090174-A1 | COMPOSITIONS FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS AND METHODS FOR THE SYNTHESIS AND USE THEREOF | BRYET US, INC. (US) | 2026-04-30 | — | — | WO | claimed |
| WO-2026090172-A1 | CELL CULTURE SYSTEMS COMPRISING MICROPATTERNED ARRAYS AND METHODS OF USE | ALTIS BIOSYSTEMS, INC. (US) | 2026-04-30 | — | — | WO | claimed |
| EP-4728051-A1 | STANDARDISING PLURIPOTENT STEM CELLS | United Kingdom Research and Innovation (GB) | 2026-04-22 | — | — | EP | claimed |
| EP-4714459-A1 | COMPOSITION FOR PREVENTING OR TREATING SALIVARY GLAND DISEASES, COMPRISING EPITHELIAL PROGENITOR CELLS OR STEM CELLS IN MINOR SALIVARY GLAND DUCT | UIF (University Industry Foundation), Yonsei University (KR) | 2026-03-25 | — | — | EP | claimed |
| EP-0279343-A2 | Combinations of anthelmintically active agents | BAYER AG (DE) | 1988-08-24 | — | — | EP | claimed |
| EP-0114277-B1 | CARNIVORE ANTHELMINTICS | MILES LABORATORIES, INC. (US) | 1987-02-04 | — | — | EP | claimed |
| EP-0156277-A2 | Stabilized anthelmintic formulations | BAYER AG (DE) | 1985-10-02 | — | — | EP | claimed |
| EP-0146573-A1 | PHARMACEUTICAL COMPOSITIONS WITH ANTHELMINTIC ACTIVITY, DOSAGE UNITS THEREOF AND METHOD FOR TREATING HELMINTHIASIS IN ANIMALS | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-07-03 | — | — | EP | claimed |
| WO-1984004677-A1 | PHARMACEUTICAL COMPOSITIONS WITH ANTHELMINTIC ACTIVITY, DOSAGE UNITS THEREOF AND METHOD FOR TREATING HELMINTHIASIS IN ANIMALS | HOECHST AG (DE) | 1984-12-06 | — | — | WO | claimed |
| EP-0114277-A1 | Carnivore anthelmintics | MILES LABORATORIES, INC. (US) | 1984-08-01 | — | — | EP | claimed |
| US-4447414-A | PASTE FORMULATIONS OF FEBANTEL AND PRAZIQUANTEL | CUTTER LABORATORIES, INC. (US) | 1984-05-08 | — | — | US | claimed |
| EP-0009215-B1 | ENDOPARASITICIDE PASTES FOR HORSES | BAYER AG (DE) | 1982-01-06 | — | — | EP | claimed |
| US-4283400-A | Medicated animal feed based on liver meal | BAYER AKTIENGESELLSCHAFT (DE) | 1981-08-11 | — | — | US | claimed |
| EP-0009215-A1 | Endoparasiticide pastes for horses | BAYER AG (DE) | 1980-04-02 | — | — | EP | claimed |