Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRND | Q07001 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672734 | 0.76 | CPN1 (0.39) | SLC6A2SLC6A3SLC6A4CHRM1 | |
| SCHEMBL4674063 | 0.75 | SLC6A2 (0.40) | SLC6A2SLC6A3HTR2CCHRNA1CHRNG | |
| Bromide SCHEMBL11094811 | 0.75 | MAOA (0.49) | HTR2CGABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL4671332 | 0.72 | MEN1 (0.66) | HTR2CGABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL4676045 | 0.72 | MEN1 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4MEN1 | |
| SCHEMBL4673078 | 0.72 | CES2 (0.42) | SLC6A2SLC6A3SLC6A4CHRM1 | |
| SCHEMBL4670637 | 0.72 | CES2 (0.39) | MEN1CYP2D6KMT2ANPC1RAB9A | |
| Bromide SCHEMBL10966281 | 0.71 | MEN1 (0.64) | HTR2CGABRDGABRA1GABRB1GABRA5 | |
| Hydrochloric Acid SCHEMBL16432330 | 0.71 | MEN1 (0.69) | HTR2CGABRDGABRA1GABRB1GABRA5 | |
| Hydrochloric Acid SCHEMBL23722031 | 0.70 | SLC6A2 (0.45) | SLC6A2SLC6A3HTR2CSLC6A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899324-A2 | BENZIMIDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | Theravance, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006127815-A2 | BENZIMIDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE, INC. (US) | 2006-11-30 | — | — | WO | disclosed |