Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 9/20 | 0.53 |
| ▸ | CA2 | P00918 | 9/20 | 0.53 |
| ▸ | CA9 | Q16790 | 9/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 9/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL985851 | 0.90 | MTNR1B (0.56) | MTNR1BTSHRCA1CA2CA9 | |
| SCHEMBL985641 | 0.87 | CA1 (0.54) | MTNR1BTSHRCA1CA2CA9 | |
| SCHEMBL987511 | 0.87 | CA1 (0.54) | MTNR1BTSHRCA1CA2CA9 | |
| SCHEMBL4669566 | 0.87 | CA1 (0.54) | MTNR1BTSHRCA1CA2CA9 | |
| SCHEMBL985355 | 0.86 | TSHR (0.58) | MTNR1BTSHRCA1CA2CA9 | |
| SCHEMBL4673800 | 0.85 | MTNR1B (0.52) | MTNR1BTSHRCA1CA2CA9 | |
| SCHEMBL4673855 | 0.84 | TSHR (0.51) | MTNR1BTSHRCA1CA2CA9 | |
| SCHEMBL987237 | 0.82 | MTNR1B (0.51) | MTNR1BTSHRCA1CA2CA9 | |
| SCHEMBL4669565 | 0.82 | TSHR (0.53) | MTNR1BTSHRCA1CA2CA9 | |
| SCHEMBL4674938 | 0.80 | CA1 (0.53) | MTNR1BTSHRCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732898-B1 | TETRAHYDROISOQUINOLINE- AND TETRAHYDROBENZAZEPINE DERIVATIVES AS IGF-1R INHIBITORS | ANALYTECON SA (CH) | 2008-01-23 | — | — | EP | disclosed |