Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.73 |
| ▸ | ACHE | P22303 | 2/20 | 0.73 |
| ▸ | HTR3A | P46098 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | SORD | Q00796 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676103 | 0.86 | BCHE (0.96) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL2674037 | 0.86 | BCHE (0.90) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL717865 | 0.84 | BCHE (1.00) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL2241920 | 0.84 | BCHE (1.00) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL531762 | 0.83 | HTR3A (1.00) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL5309716 | 0.81 | BCHE (0.71) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL2674838 | 0.81 | TP53 (1.00) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL21047636 | 0.80 | BCHE (0.69) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL22481379 | 0.80 | TRPC3 (0.75) | BCHEACHEHTR3ATP53TRPC3 | |
| SCHEMBL8880315 | 0.80 | HTR3A (0.82) | BCHEACHEHTR3ATP53TRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |