Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA3 | P07451 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | CA6 | P23280 | 2/20 | 0.41 |
| ▸ | CA5A | P35218 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217625 | 0.82 | ALDH1A1 (0.48) | ALDH1A1CYP3A4MAPK1HTR2AHTR2C | |
| SCHEMBL2303097 | 0.81 | GAA (0.43) | ALDH1A1CYP3A4HTR2AHTR2CCA1 | |
| SCHEMBL765653 | 0.81 | ALDH1A1 (0.49) | ALDH1A1CYP3A4MAPK1HTR2AHTR2C | |
| SCHEMBL2100232 | 0.81 | HTR2A (0.51) | ALDH1A1HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL2798239 | 0.78 | MAPT (0.50) | ALDH1A1CYP3A4MAPK1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL5271819 | 0.76 | MAPT (0.49) | ALDH1A1CYP3A4MAPK1HTR2AHTR2C | |
| SCHEMBL31713765 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HTR2AHTR2CKCNH2MMP1 | |
| SCHEMBL15152636 | 0.74 | MAPT (0.46) | ALDH1A1CYP3A4MAPK1HTR2AHTR2C | |
| SCHEMBL15152638 | 0.74 | MAPT (0.46) | ALDH1A1CYP3A4MAPK1HTR2AHTR2C | |
| SCHEMBL21032959 | 0.71 | ALDH1A1 (0.41) | ALDH1A1CYP3A4MAPK1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |