Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 9/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4674832 | 0.92 | GRIN2B (0.63) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4674828 | 0.92 | GRIN2B (0.63) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL7228618 | 0.89 | GRIN2B (0.61) | GRIN2BGRIN1HTR1AHTR2CSIGMAR1 | |
| SCHEMBL8114274 | 0.84 | GRIN2B (0.60) | GRIN2BGRIN1HTR1AHTR2CSIGMAR1 | |
| SCHEMBL8110695 | 0.78 | SIGMAR1 (0.67) | GRIN2BGRIN1HTR1AHTR2CSIGMAR1 | |
| SCHEMBL4672713 | 0.78 | GRIN2B (0.66) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4672719 | 0.78 | GRIN2B (0.66) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4672490 | 0.75 | GRIN2B (0.62) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4672495 | 0.75 | GRIN2B (0.62) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL8116065 | 0.75 | HTR1A (0.67) | GRIN2BGRIN1HTR1AHTR2CSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068202-B1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1068202-A1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999048891-A1 | 1-(3-HETEROARYLPROPYL- OR -PROP-2-ENYL)-4-BENZYLPIPERIDINES USED AS NMDA RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 1999-09-30 | — | — | WO | disclosed |