Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19317518 | 0.89 | ALDH1A1 (0.59) | ALDH1A1MAPK1MGLLKDM2BPARP10 | |
| SCHEMBL31279890 | 0.89 | ALDH1A1 (0.59) | ALDH1A1MAPK1MGLLKDM2BPARP10 | |
| SCHEMBL654047 | 0.85 | HTR2A (0.49) | ALDH1A1MGLLSRD5A2 | |
| SCHEMBL6032432 | 0.84 | ALDH1A1 (0.67) | ALDH1A1MAPK1MGLLKDM2BPARP10 | |
| SCHEMBL4674650 | 0.82 | MGLL (0.54) | ALDH1A1MAPK1MGLLKDM2BNPC1 | |
| SCHEMBL4675888 | 0.81 | MEN1 (0.58) | ALDH1A1MAPK1MGLLKDM2BPARP10 | |
| SCHEMBL4675008 | 0.81 | NPC1 (0.71) | ALDH1A1MAPK1MGLLKDM2BLMNA | |
| Hydrochloric Acid SCHEMBL11617476 | 0.80 | MEN1 (0.60) | ALDH1A1MAPK1MGLLKDM2BPARP10 | |
| SCHEMBL10807356 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPK1MGLLKDM2BPARP10 | |
| SCHEMBL9041510 | 0.79 | SRD5A2 (0.47) | ALDH1A1MGLLSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |