Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.44 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4673738 | 0.93 | PTPN1 (0.52) | PTPN1NCEH1NR1H4 | |
| SCHEMBL4676179 | 0.91 | NCEH1 (0.40) | PTPN1NCEH1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL4674024 | 0.87 | PTPN1 (0.43) | PTPN1NCEH1NR1H4SMN1; SMN2KMT2A | |
| SCHEMBL4673960 | 0.86 | NCEH1 (0.40) | PTPN1NCEH1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL4670790 | 0.85 | PTPN1 (0.44) | PTPN1NCEH1NR1H4SMN1; SMN2CYP2C19 | |
| SCHEMBL4670309 | 0.83 | PTPN1 (0.43) | PTPN1NR1H4THRB | |
| SCHEMBL4673316 | 0.81 | PTPN1 (0.40) | PTPN1NR1H4 | |
| SCHEMBL4673276 | 0.81 | NCEH1 (0.43) | PTPN1NCEH1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL4728486 | 0.80 | NR1H4 (0.42) | PTPN1NR1H4THRB | |
| SCHEMBL4670614 | 0.80 | PTPN1 (0.39) | PTPN1NR1H4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |