Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4673738 | 0.88 | PTPN1 (0.52) | NR1H4PTPN1SIRT3 | |
| SCHEMBL4670309 | 0.87 | PTPN1 (0.43) | NR1H4PTPN1SIRT3THRATHRB | |
| SCHEMBL4670614 | 0.87 | PTPN1 (0.39) | NR1H4PTPN1SIRT3KDM7A | |
| SCHEMBL4673725 | 0.86 | NR1H4 (0.41) | NR1H4PTPN1SIRT3KDM5AKDM7A | |
| SCHEMBL4673316 | 0.85 | PTPN1 (0.40) | NR1H4PTPN1SIRT3FAAH | |
| SCHEMBL4672720 | 0.84 | PTPN1 (0.39) | NR1H4PTPN1SIRT3 | |
| SCHEMBL4674317 | 0.81 | NR1H4 (0.49) | NR1H4PTPN1SIRT3KDM5AKDM7A | |
| SCHEMBL4675973 | 0.80 | PTPN1 (0.44) | NR1H4PTPN1THRB | |
| SCHEMBL4674314 | 0.80 | NR1H4 (0.48) | NR1H4PTPN1SIRT3KDM5AKDM7A | |
| SCHEMBL4676179 | 0.77 | NCEH1 (0.40) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |