Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | HTR6 | P50406 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | TDO2 | P48775 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4673448 | 0.90 | SLC6A4 (1.00) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| Bromide SCHEMBL7867371 | 0.88 | SLC6A4 (0.97) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL12285207 | 0.84 | SLC6A4 (0.67) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL4670751 | 0.84 | SLC6A4 (0.81) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL4671416 | 0.84 | SLC6A4 (0.81) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL7859785 | 0.84 | SLC6A4 (0.72) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL7867998 | 0.84 | SLC6A4 (0.63) | SLC6A4KDM4ELMNAPOLBHTR1A | |
| SCHEMBL18324732 | 0.82 | TDO2 (0.81) | SLC6A4HTR1ATDO2 | |
| SCHEMBL6976036 | 0.82 | HTR1A (0.63) | SLC6A4KDM4ELMNAHTR1AALOX15 | |
| SCHEMBL3340115 | 0.81 | SLC6A4 (0.63) | SLC6A4KDM4ELMNAPOLBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |