SCHEMBL467651

SCHEMBL467651

[c]1cc2c(nn1)-c1cccnc1CCC2

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 1/20 0.32
CYP19A1 P11511 3/20 0.32
TBXAS1 P24557 2/20 0.32
DUSP10 Q9Y6W6 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MAPK14 Q16539 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL118747 0.80 DRD4 (0.45) NPY5RCYP19A1
SCHEMBL152894 0.73 KDM4E (0.41) L3MBTL1
SCHEMBL30724388 0.71 CHRM2 (0.41) NPY5RCYP19A1DUSP10L3MBTL1
SCHEMBL3617507 0.69
SCHEMBL467418 0.69 CYP2A6 (0.42) NPY5RCYP19A1L3MBTL1
SCHEMBL467462 0.69 BCHE (0.41)
SCHEMBL149347 0.67
SCHEMBL29395766 0.67
Hydrochloric Acid SCHEMBL695996 0.66 TSHR (0.40) NPY5RCYP19A1L3MBTL1
SCHEMBL3602680 0.66 GAA (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230372337-A1 Combination Therapy Comprising an AXL Inhibitor BERGENBIO ASA (NO) 2023-11-23 US disclosed
US-20230250169-A1 AXL Inhibitors for Antiviral Therapy BERGENBIO ASA (NO) 2023-08-10 US disclosed
US-20230149397-A1 Combination Therapy with AXL Inhibitor and Immune Checkpoint Modulator or Oncolytic Virus BERGENBIO ASA (NO) 2023-05-18 US disclosed
US-20230151100-A1 Method of Selecting Patients for Treatment with a Combination of an AXL Inhibitor and an Immune Checkpoint Modulator BERGENBIO ASA (NO) 2023-05-18 US disclosed
EP-4138823-A1 METHOD OF SELECTING PATIENTS FOR TREATMENT WITH A COMBINATION OF AN AXL INHIBITOR AND AN IMMUNE CHECKPOINT MODULATOR BerGenBio ASA (NO) 2023-03-01 EP disclosed
EP-4132652-A1 AXL INHIBITORS FOR ANTIVIRAL THERAPY BerGenBio ASA (NO) 2023-02-15 EP disclosed
EP-4125908-A1 COMBINATION THERAPY COMPRISING AN AXL INHIBITOR BerGenBio ASA (NO) 2023-02-08 EP disclosed
US-11534440-B2 Combination therapy with Axl inhibitor and immune checkpoint modulator or oncolytic virus BERGENBIO ASA (NO) 2022-12-27 US disclosed
US-20210379064-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER MIDCAP FINANCIAL TRUST 2021-12-09 US disclosed
WO-2021214492-A1 METHOD OF SELECTING PATIENTS FOR TREATMENT WITH A COMBINATION OF AN AXL INHIBITOR AND AN IMMUNE CHECKPOINT MODULATOR BERGENBIO ASA (NO) 2021-10-28 WO disclosed
EP-3302481-A1 COMBINATION THERAPY WITH AXL INHIBITOR AND IMMUNE CHECKPOINT MODULATOR OR ONCOLYTIC VIRUS BerGenBio ASA (NO) 2018-04-11 EP disclosed
US-20170042891-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS, INC. 2017-02-16 US disclosed
WO-2016193680-A1 COMBINATION THERAPY WITH AXL INHIBITOR AND IMMUNE CHECKPOINT MODULATOR OR ONCOLYTIC VIRUS BERGENBIO AS (NO) 2016-12-08 WO disclosed
EP-2387395-B1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS INC (US) 2014-10-15 EP disclosed
US-20130338161-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS INC (US) 2013-12-19 US disclosed
US-8546433-B2 Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer RIGEL PHARMACEUTICALS, INC. (US) 2013-10-01 US disclosed
EP-2387395-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER Rigel Pharmaceuticals, Inc. (US) 2011-11-23 EP disclosed
US-8040491-B2 Exposure method, substrate stage, exposure apparatus, and device manufacturing method NIKON CORPORATION (JP) 2011-10-18 US disclosed
US-20100196511-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS, INC. (US) 2010-08-05 US disclosed
WO-2010083465-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS, INC. (US) 2010-07-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100196511-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET NPY5R 2603/4885CYP19A1 4044/4885TBXAS1 2983/4885
US-20230149397-A1 Combination Therapy with AXL Inhibitor and Immune Checkpoint Modulator or Oncolytic Virus AXL, CD274, HAVCR2 NPY5R 2927/4885CYP19A1 4503/4885TBXAS1 4426/4885
US-11534440-B2 Combination therapy with Axl inhibitor and immune checkpoint modulator or oncolytic virus AXL, CD274, HAVCR2 NPY5R 3429/4885CYP19A1 4518/4885TBXAS1 4512/4885
US-20230372337-A1 Combination Therapy Comprising an AXL Inhibitor AXL, CD274, CD47 NPY5R 3502/4885CYP19A1 4422/4885TBXAS1 4090/4885
US-20230250169-A1 AXL Inhibitors for Antiviral Therapy FLT3, AXL, SARS1 NPY5R 3017/4885CYP19A1 4234/4885TBXAS1 2401/4885
US-20170042891-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET NPY5R 2603/4885CYP19A1 4044/4885TBXAS1 2983/4885
US-20210379064-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET NPY5R 2603/4885CYP19A1 4044/4885TBXAS1 2983/4885
US-20230151100-A1 Method of Selecting Patients for Treatment with a Combination of an AXL Inhibitor and an Immune Checkpoint Modulator STK11, MERTK, AXL NPY5R 3126/4885CYP19A1 3045/4885TBXAS1 3259/4885
US-20130338161-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET NPY5R 2603/4885CYP19A1 4044/4885TBXAS1 2983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.