SCHEMBL467681

SCHEMBL467681

c1cc2c(c(OCCCCN3CCCCC3)c1)CCNC2

nearest known ligand 0.76

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 12/20 0.76
TRPM2 O94759 1/20 0.61
PARP1 P09874 1/20 0.61
HTR2A P28223 2/20 0.52
HTR7 P34969 2/20 0.52
HTR6 P50406 2/20 0.52
CD274 Q9NZQ7 1/20 0.52
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 2/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C19 P33261 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14287592 0.96 HRH3 (0.82) HRH3TRPM2PARP1HTR2AHTR7
Hydrochloric Acid SCHEMBL5107481 0.95 HRH3 (0.80) HRH3TRPM2PARP1HTR2AHTR7
SCHEMBL6658901 0.86 HRH3 (1.00) HRH3TRPM2PARP1HTR2AHTR7
Hydrochloric Acid SCHEMBL5106963 0.85 HRH3 (0.98) HRH3TRPM2PARP1HTR2AHTR7
SCHEMBL30101340 0.81 HRH3 (0.69) HRH3TRPM2PARP1TDP1CYP1A2
SCHEMBL491852 0.81 HRH3 (0.62) HRH3TRPM2PARP1HTR2AHTR7
SCHEMBL21744253 0.81 HRH3 (0.56) HRH3CD274CYP2D6
SCHEMBL5101030 0.78 HRH3 (0.56) HRH3HTR2AHTR7CD274
SCHEMBL4718360 0.78 HRH3 (0.48) HRH3CD274
SCHEMBL20983791 0.78 HRH3 (0.51) HRH3TRPM2PARP1CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015164586-A1 TARGETING PARP1 FOR TREATMENT OF TSC AND CANCERS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2015-10-29 WO claimed
EP-2387403-A1 METHOD OF TREATING CANCER Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) 2011-11-23 EP claimed
US-20110253692-A1 Electrical heater for vehicle windshields and windows SCHAUBLE RICHARD EGON 2011-10-20 US claimed
WO-2010082821-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO claimed
EP-3506982-A1 MIF INHIBITORS AND METHODS OF USE THEREOF The Johns Hopkins University (US) 2019-07-10 EP disclosed
WO-2018045250-A1 MIF INHIBITORS AND METHODS OF USE THEREOF THE JOHNS HOPKINS UNIVERSITY (US) 2018-03-08 WO disclosed
WO-2015164586-A1 TARGETING PARP1 FOR TREATMENT OF TSC AND CANCERS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2015-10-29 WO disclosed
EP-2619331-A1 METHODS OF TREATING CANCER COMPRISING TARGETING NQO1 The Board of Regents of The University of Texas System (US) 2013-07-31 EP disclosed
WO-2012065106-A2 COMPOUNDS AND RELATED METHODS FOR MANIPULATING PARP-1-DEPENDENT CELL DEATH DAWSON TED M (US) 2012-05-18 WO disclosed
EP-2440203-A1 SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE. POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF The Governors Of The University Of Alberta (CA) 2012-04-18 EP disclosed
WO-2012040492-A1 METHODS OF TREATING CANCER COMPRISING TARGETING NQO1 THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-03-29 WO disclosed
EP-2387403-A1 METHOD OF TREATING CANCER Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) 2011-11-23 EP disclosed
US-20110253692-A1 Electrical heater for vehicle windshields and windows SCHAUBLE RICHARD EGON 2011-10-20 US disclosed
WO-2010139069-A1 SMALL MOLECULE INHIBITORS OF POLYNUCLEOTIDE KINASE/PHOSPHATASE. POLY(ADP-RIBOSE) POLYMERASE AND USES THEREOF THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2010-12-09 WO disclosed
WO-2010082821-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO disclosed
WO-2010082813-A1 METHOD OF TREATING CANCER ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) 2010-07-22 WO disclosed
EP-2082229-A2 COMPOSITIONS AND METHODS FOR TISSUE-BASED PROTEIN TRUNCATION TEST FOR DISEASE DIAGNOSIS Regents of the University of Colorado (US) 2009-07-29 EP disclosed
EP-1968583-A2 COMPOUNDS, SCREENS, AND METHODS OF TREATMENT PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2008-09-17 EP disclosed
WO-2008100340-A2 COMPOSITIONS AND METHODS FOR TISSUE-BASED PROTEIN TRUNCATION TEST FOR DISEASE DIAGNOSIS REGENTS OF THE UNIVERSITY OF COLORADO (US) 2008-08-21 WO disclosed
WO-2007075772-A2 COMPOUNDS, SCREENS, AND METHODS OF TREATMENT PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2007-07-05 WO disclosed