Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 6/20 | 0.54 |
| ▸ | HTR1A | P08908 | 4/20 | 0.54 |
| ▸ | DRD1 | P21728 | 4/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | HTR7 | P34969 | 3/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263189 | 0.85 | DRD3 (0.58) | DRD3HTR1ADRD1DRD2HTR2A | |
| SCHEMBL11281497 | 0.82 | DRD3 (0.57) | HRH3DRD3HTR1ADRD1DRD2 | |
| SCHEMBL14287592 | 0.81 | HRH3 (0.82) | HRH3HTR2AHTR7HRH1CD274 | |
| Hydrochloric Acid SCHEMBL5107481 | 0.80 | HRH3 (0.80) | HRH3HTR2AHTR7HRH1CD274 | |
| SCHEMBL467681 | 0.78 | HRH3 (0.76) | HRH3HTR2AHTR7CD274 | |
| SCHEMBL21743757 | 0.78 | PLD1 (0.52) | — | |
| SCHEMBL11307197 | 0.77 | HTR7 (0.67) | DRD3HTR1ADRD1DRD2HTR2A | |
| SCHEMBL21744253 | 0.74 | HRH3 (0.56) | HRH3DRD1DRD5DRD4MAOB | |
| SCHEMBL8083866 | 0.73 | HTR1A (0.60) | HRH3DRD3HTR1ADRD1DRD2 | |
| SCHEMBL6658901 | 0.72 | HRH3 (1.00) | HRH3HTR2AHTR7HRH1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | claimed |