Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.49 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4684369 | 0.85 | CNR1 (0.53) | CNR1CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL4679252 | 0.82 | HTT (0.44) | CNR1KDM4EALDH1A1 | |
| SCHEMBL4681538 | 0.78 | CNR1 (0.58) | CNR1CNR2KDM4EALDH1A1HPGD | |
| SCHEMBL4681583 | 0.76 | CNR1 (0.53) | CNR1CNR2 | |
| SCHEMBL4676935 | 0.75 | CNR1 (0.62) | CNR1CNR2PDE4APDE4BPDE4C | |
| SCHEMBL4681752 | 0.74 | CNR1 (0.52) | CNR1CNR2KDM4EALOX15 | |
| SCHEMBL4676879 | 0.74 | CNR1 (0.50) | CNR1CNR2 | |
| SCHEMBL4680943 | 0.74 | CNR1 (0.50) | CNR1CNR2 | |
| SCHEMBL4676765 | 0.73 | CNR1 (0.50) | CNR1CNR2 | |
| SCHEMBL4684187 | 0.73 | CNR1 (0.42) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-B1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | claimed |