Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5881510 | 0.99 | RAB9A (0.47) | RAB9AALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL4680022 | 0.86 | SMN1; SMN2 (0.47) | RAB9AALDH1A1SMN1; SMN2MAPTTHRB | |
| Hydrochloric Acid SCHEMBL4684420 | 0.85 | SMN1; SMN2 (0.46) | RAB9AALDH1A1SMN1; SMN2MAPTTHRB | |
| SCHEMBL5881498 | 0.84 | RAB9A (0.52) | RAB9AALDH1A1SMN1; SMN2MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL4680476 | 0.83 | RAB9A (0.51) | RAB9AALDH1A1SMN1; SMN2MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL4683180 | 0.83 | BCHE (0.42) | RAB9ASMN1; SMN2NPC1MAPTTHRB | |
| SCHEMBL4681191 | 0.82 | NPSR1 (0.41) | RAB9AALDH1A1MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4680912 | 0.81 | NPSR1 (0.41) | RAB9AALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4681022 | 0.80 | TPSAB1 (0.39) | KMT2A | |
| Hydrochloric Acid SCHEMBL4681632 | 0.79 | TPSAB1 (0.38) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343775-B1 | PIPERAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-06-04 | — | — | EP | disclosed |
| US-7022707-B2 | Piperazine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-20040235859-A1 | Novel piperazine derivatives | ADAMS DAVID REGINALD (GB) | 2004-11-25 | — | — | US | disclosed |
| US-20020143020-A1 | Novel piperazine derivatives | VERNALIS RESEARCH LIMITED (GB) | 2002-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020143020-A1 | Novel piperazine derivatives | CYP4B1, UGT1A1, CYP1B1 | RAB9A 1070/4885ALDH1A1 4/4885SMN1; SMN2 1517/4885 |
| US-20040235859-A1 | Novel piperazine derivatives | CYP4B1, UGT1A1, CYP1B1 | RAB9A 1070/4885ALDH1A1 4/4885SMN1; SMN2 1517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.