Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4673655 | 0.94 | CCR3 (0.54) | CCR3SMN1; SMN2MAPTALOX12NPSR1 | |
| SCHEMBL4784810 | 0.91 | SMN1; SMN2 (0.46) | CCR3SMN1; SMN2MAPTALOX12NPSR1 | |
| SCHEMBL4679788 | 0.91 | CCR3 (0.54) | CCR3SMN1; SMN2MAPTALOX12NPSR1 | |
| SCHEMBL4676806 | 0.91 | CCR3 (0.53) | CCR3SMN1; SMN2MAPTALOX12NPSR1 | |
| SCHEMBL4678302 | 0.89 | CCR3 (0.52) | CCR3LMNAHTTCYP3A4ABCB11 | |
| SCHEMBL4674120 | 0.88 | CCR3 (0.51) | CCR3CCR1LMNAHTTCYP3A4 | |
| SCHEMBL4677131 | 0.85 | EPHX2 (0.49) | CCR3SIGMAR1CACNA1GBCHEACHE | |
| SCHEMBL4674550 | 0.85 | CCR3 (0.49) | CCR3CCR1LMNACYP3A4ABCB11 | |
| SCHEMBL4674096 | 0.85 | CCR3 (0.57) | CCR3SIGMAR1DRD4CACNA1GBCHE | |
| SCHEMBL4673649 | 0.84 | CCR3 (0.57) | CCR3SIGMAR1DRD4CACNA1GBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196404-B1 | PIPERAZINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2008-01-23 | — | — | EP | claimed |
| US-6562825-B1 | For treating inflammatory disease including asthma and allergic diseases, as well as autoimmune pathologies | ASTRAZENECA UK LIMITED (GB) | 2003-05-13 | — | — | US | claimed |
| EP-1196404-B1 | PIPERAZINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2008-01-23 | — | — | EP | disclosed |
| US-6562825-B1 | For treating inflammatory disease including asthma and allergic diseases, as well as autoimmune pathologies | ASTRAZENECA UK LIMITED (GB) | 2003-05-13 | — | — | US | disclosed |