Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4676806 | 0.93 | CCR3 (0.53) | CCR3SIGMAR1CCR1CHRM1CYP3A4 | |
| SCHEMBL4673655 | 0.92 | CCR3 (0.54) | CCR3SIGMAR1CCR1CHRM1CYP3A4 | |
| SCHEMBL4677003 | 0.91 | CCR3 (0.51) | CCR3SIGMAR1CCR1CHRM1CYP3A4 | |
| SCHEMBL4678302 | 0.91 | CCR3 (0.52) | CCR3CHRM1CYP3A4ABCB11LMNA | |
| SCHEMBL4674120 | 0.90 | CCR3 (0.51) | CCR3SIGMAR1CCR1CHRM1CYP3A4 | |
| SCHEMBL4674550 | 0.87 | CCR3 (0.49) | CCR3SIGMAR1CCR1CHRM1CYP3A4 | |
| SCHEMBL4674096 | 0.87 | CCR3 (0.57) | CCR3SIGMAR1DRD4CACNA1GBCHE | |
| SCHEMBL4673649 | 0.86 | CCR3 (0.57) | CCR3SIGMAR1DRD4CACNA1GBCHE | |
| SCHEMBL4674446 | 0.86 | ALDH1A1 (0.56) | CCR3SMN1; SMN2ALDH1A1KMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL4680263 | 0.86 | CCR3 (0.56) | CCR3SIGMAR1DRD4CACNA1GBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196404-B1 | PIPERAZINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2008-01-23 | — | — | EP | claimed |
| US-6562825-B1 | For treating inflammatory disease including asthma and allergic diseases, as well as autoimmune pathologies | ASTRAZENECA UK LIMITED (GB) | 2003-05-13 | — | — | US | claimed |
| EP-1196404-B1 | PIPERAZINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2008-01-23 | — | — | EP | disclosed |
| US-6562825-B1 | For treating inflammatory disease including asthma and allergic diseases, as well as autoimmune pathologies | ASTRAZENECA UK LIMITED (GB) | 2003-05-13 | — | — | US | disclosed |