Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677003 | 0.91 | CCR3 (0.51) | SMN1; SMN2NPSR1MAPTALOX12LMNA | |
| SCHEMBL4673655 | 0.84 | CCR3 (0.54) | SMN1; SMN2NPSR1MAPTALOX12LMNA | |
| SCHEMBL4679788 | 0.82 | CCR3 (0.54) | SMN1; SMN2NPSR1MAPTALOX12LMNA | |
| SCHEMBL4676806 | 0.82 | CCR3 (0.53) | SMN1; SMN2NPSR1MAPTALOX12LMNA | |
| SCHEMBL4678302 | 0.80 | CCR3 (0.52) | LMNAHTTPOLBCCR3ALDH1A1 | |
| SCHEMBL4674120 | 0.79 | CCR3 (0.51) | LMNAHTTCCR3CCR1KMT2A | |
| SCHEMBL4677131 | 0.77 | EPHX2 (0.49) | CCR3 | |
| SCHEMBL4674550 | 0.77 | CCR3 (0.49) | LMNACCR3CCR1KMT2AMEN1 | |
| SCHEMBL4674446 | 0.76 | ALDH1A1 (0.56) | SMN1; SMN2NPSR1MAPK1TSHRCCR3 | |
| SCHEMBL4674096 | 0.76 | CCR3 (0.57) | CCR3AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196404-B1 | PIPERAZINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2008-01-23 | — | — | EP | disclosed |