SCHEMBL4677930

SCHEMBL4677930

CCOC(=O)C(C)(C)Oc1ccc(C(C)(NC)c2cc(-c3ccc(OC(F)(F)F)cc3)nn2C)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 8/20 0.39
ABCB11 O95342 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
TSHR P16473 1/20 0.39
HTR2A P28223 1/20 0.39
PMP22 Q01453 1/20 0.39
FBP1 P09467 1/20 0.39
CNR1 P21554 2/20 0.38
PPARD Q03181 5/20 0.37
PPARG P37231 4/20 0.37
GCGR P47871 5/20 0.36
MRGPRX4 Q96LA9 1/20 0.35
POLB P06746 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
SCN10A Q9Y5Y9 1/20 0.35
ELANE P08246 1/20 0.34
FAAH O00519 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4677889 0.93 FBP1 (0.40) PPARAABCB11CYP1A2CYP3A4TSHR
SCHEMBL4681943 0.90 PPARA (0.37) PPARAABCB11CYP1A2CYP3A4TSHR
SCHEMBL4679441 0.89 PPARD (0.45) PPARAPPARDPPARGGCGR
SCHEMBL4678234 0.89 GCGR (0.36) PPARAABCB11CYP1A2CYP3A4TSHR
SCHEMBL4679123 0.85 PPARA (0.45) PPARAFBP1PPARDPPARG
SCHEMBL4681991 0.85 PPARA (0.43) PPARAABCB11CYP1A2CYP3A4TSHR
SCHEMBL4677865 0.84 FBP1 (0.39) PPARATSHRFBP1CNR1PPARD
SCHEMBL6528502 0.84 PPARA (0.37) PPARAFBP1CNR1PPARDPPARG
SCHEMBL4679444 0.83 FBP1 (0.38) PPARAABCB11CYP1A2CYP3A4TSHR
SCHEMBL4683027 0.81 PPARA (0.45) PPARAPPARDPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1513796-B1 PHENYLOXYALKANOIC ACID DERIVATIVES AS HPPAR ACTIVATORS SMITHKLINE BEECHAM CORP (US) 2008-02-13 EP claimed
US-7241793-B2 Phenyloxyalkanonic acid derivatives as hPPAR activators SMITHKLINE BEECHAM CORPORATION (US) 2007-07-10 US claimed
US-20050222424-A1 Phenyloxyalkanonic acid derivatives as hppar activators SMITHKLINE BEECHAM CORPORATION 2005-10-06 US claimed
EP-1513796-B1 PHENYLOXYALKANOIC ACID DERIVATIVES AS HPPAR ACTIVATORS SMITHKLINE BEECHAM CORP (US) 2008-02-13 EP disclosed
US-7241793-B2 Phenyloxyalkanonic acid derivatives as hPPAR activators SMITHKLINE BEECHAM CORPORATION (US) 2007-07-10 US disclosed
US-20050222424-A1 Phenyloxyalkanonic acid derivatives as hppar activators SMITHKLINE BEECHAM CORPORATION 2005-10-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050222424-A1 Phenyloxyalkanonic acid derivatives as hppar activators CEL, HPN, LIPA PPARA 54/4885ABCB11 18/4885CYP1A2 688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.