Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 3/20 | 0.52 |
| ▸ | CNR1 | P21554 | 11/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680784 | 0.85 | CNR1 (0.55) | CNR1PKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4684331 | 0.83 | LIPE (0.54) | LIPECNR1CNR2 | |
| SCHEMBL4677739 | 0.79 | LIPE (0.52) | LIPECNR1CNR2 | |
| SCHEMBL4684381 | 0.78 | LIPE (0.50) | LIPECNR1NPC1RAB9ACNR2 | |
| SCHEMBL4680846 | 0.78 | LIPE (0.48) | LIPECNR1CNR2 | |
| SCHEMBL4680352 | 0.77 | LIPE (0.47) | LIPECNR1CNR2 | |
| SCHEMBL4677613 | 0.77 | LIPE (0.47) | LIPECNR1CNR2 | |
| SCHEMBL4682579 | 0.76 | LIPE (0.47) | LIPECNR1CNR2 | |
| SCHEMBL4679631 | 0.76 | LIPE (0.47) | LIPECNR1CNR2 | |
| SCHEMBL4677885 | 0.76 | LIPE (0.47) | LIPECNR1NPC1RAB9ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-B1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | claimed |