Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 12/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680618 | 0.94 | LIPE (0.45) | LIPECNR1CNR2 | |
| SCHEMBL4677630 | 0.87 | CNR1 (0.46) | CNR1PIK3CAMTORPIK3CGCNR2 | |
| SCHEMBL4676521 | 0.85 | LIPE (0.44) | LIPECNR1PIK3CAMTORPIK3CG | |
| SCHEMBL4684182 | 0.85 | LIPE (0.46) | LIPECNR1CNR2 | |
| SCHEMBL4684381 | 0.84 | LIPE (0.50) | LIPECNR1CNR2ALDH1A1 | |
| SCHEMBL4680719 | 0.80 | CNR1 (0.49) | CNR1CNR2 | |
| SCHEMBL4684331 | 0.79 | LIPE (0.54) | LIPECNR1CNR2MEN1KMT2A | |
| SCHEMBL4677885 | 0.78 | LIPE (0.47) | LIPECNR1CNR2 | |
| SCHEMBL4680352 | 0.77 | LIPE (0.47) | LIPECNR1CNR2ALDH1A1 | |
| SCHEMBL4679631 | 0.77 | LIPE (0.47) | LIPECNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-B1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | claimed |