Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679864 | 0.91 | PTGS2 (0.37) | PTGS2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL4680787 | 0.78 | GRM5 (0.47) | PTGS2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL4681177 | 0.76 | ALDH1A1 (0.37) | MAPK1ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL4683102 | 0.76 | CYP2C19 (0.49) | PTGS2ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL11642754 | 0.72 | CNR2 (0.42) | MAPK1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4787556 | 0.70 | GRM5 (0.44) | PTGS2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL82549 | 0.69 | PTGS1 (0.62) | PTGS2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL4679862 | 0.67 | DDB1 (0.35) | PTGS2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL14007394 | 0.65 | SMN1; SMN2 (0.48) | PTGS2ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL15305300 | 0.63 | PTGS2 (0.45) | PTGS2ALDH1A1MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943247-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-07-16 | — | — | EP | claimed |
| WO-2007023245-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | claimed |