Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PPM1B | O75688 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9209640 | 0.77 | L3MBTL1 (0.61) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR | |
| SCHEMBL380982 | 0.76 | L3MBTL1 (0.46) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR | |
| SCHEMBL29998004 | 0.76 | L3MBTL1 (0.46) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR | |
| SCHEMBL4680121 | 0.76 | L3MBTL1 (0.46) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR | |
| SCHEMBL381187 | 0.74 | L3MBTL1 (0.44) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR | |
| SCHEMBL1908662 | 0.74 | L3MBTL1 (0.44) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR | |
| SCHEMBL21009822 | 0.74 | L3MBTL1 (0.44) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR | |
| SCHEMBL22495519 | 0.74 | L3MBTL1 (0.44) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR | |
| SCHEMBL493715 | 0.74 | L3MBTL1 (0.44) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR | |
| SCHEMBL8392104 | 0.74 | L3MBTL1 (0.44) | L3MBTL1ALOX15ALDH1A1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416933-B8 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1416933-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgem, Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| EP-1417190-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | Amgen Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003009847-A1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM, INC. (US) | 2003-02-06 | — | — | WO | disclosed |
| WO-2003009850-A1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC. (US) | 2003-02-06 | — | — | WO | disclosed |