SCHEMBL4680282

SCHEMBL4680282

CCN(CC1CCN(S(=O)(=O)N(C)C)CC1)C(C)Cc1ccc(C(F)(F)F)cc1.O=C(O)C(O)(C(=O)c1ccccc1)C(O)(C(=O)O)C(=O)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.44
LMNA P02545 1/20 0.42
ALDH1A1 P00352 2/20 0.42
TRPV4 Q9HBA0 3/20 0.38
RAB9A P51151 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
OPRM1 P35372 1/20 0.36
OPRD1 P41143 1/20 0.36
KCNH2 Q12809 1/20 0.36
CCR5 P51681 2/20 0.36
ADAMTS7 Q9UKP4 1/20 0.35
ADAMTS5 Q9UNA0 1/20 0.35
KMT2A Q03164 1/20 0.35
CACNA1B Q00975 1/20 0.35
MMP2 P08253 1/20 0.34
MMP13 P45452 1/20 0.34
TSHR P16473 1/20 0.34
CCR2 P41597 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4679943 0.91 CYP2D6 (0.44) CYP2D6LMNAALDH1A1OPRM1KCNH2
SCHEMBL4682885 0.88 RORC (0.40) CYP2D6KCNH2CCR5ADAMTS7ADAMTS5
SCHEMBL4680285 0.88 CYP2D6 (0.42) CYP2D6LMNAALDH1A1TRPV4RAB9A
SCHEMBL4685574 0.85 MCHR1 (0.39) CYP2D6RAB9AKCNH2CCR5
SCHEMBL4680484 0.84 CYP2D6 (0.57) CYP2D6ALDH1A1SMN1; SMN2KMT2ATSHR
SCHEMBL4682466 0.83 KMT2A (0.43) CYP2D6LMNAOPRM1KCNH2KMT2A
Water SCHEMBL4683829 0.83 TACR1 (0.37) CYP2D6RAB9ACCR5
SCHEMBL4682509 0.82 CYP2D6 (0.41) CYP2D6LMNARAB9ASMN1; SMN2KCNH2
SCHEMBL4682359 0.80 CYP2D6 (0.42) CYP2D6LMNARAB9ASMN1; SMN2KCNH2
SCHEMBL4679944 0.80 CYP2D6 (0.42) CYP2D6LMNAALDH1A1RAB9AOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1058680-B1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2008-07-09 EP disclosed
US-6319920-B1 MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY SYNTEX (U.S.A.) LLC 2001-11-20 US disclosed
EP-1058680-A1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2000-12-13 EP disclosed
WO-1999043657-A1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 1999-09-02 WO disclosed